A genetic mutation, responsible for nearly half of all cases of congenital deafness, surprisingly provides patients with an unexpected advantage: it helps wounds heal faster and reduces the risk of infection.
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(Photo: vesid) |
This discovery, recently presented at a conference in Amsterdam, Netherlands, may explain why the CX26 gene mutation is prevalent among all human populations worldwide.
The link between the CX26 gene and deafness was first identified by researcher David Kelsell from Queen Mary University in London about ten years ago. Deafness occurs only when both parents carry the CX26 gene. This gene encodes for the protein connexin 26, which is crucial for metabolic exchanges between cells. Connexins combine to form tiny channels that span cell membranes, allowing for metabolic communication between cells.
The mutation of the CX26 gene causing deafness is relatively common among residents of Europe, Asia, and Africa. David Kelsell and his colleagues assert that this mutated gene would not be widespread if it did not confer any advantages.
Connexin 26 is also found in the skin. Researchers have demonstrated in laboratory settings that cells carrying the mutated version of this protein have enhanced wound healing capabilities and better antibacterial properties. They noted plans to investigate the effects of CX26 on other tissues, particularly in the intestinal lining.
