Scientists from the University of Oxford in the UK have discovered a gene called LZTF1, which doubles the risk of lung failure and death from Covid-19.
Gene LZTF1 – believed to increase the risk of infection and death from Covid-19. (Illustrative image: BBC)
They reported that 60% of people of South Asian descent and 15% of people of European descent carry this high-risk gene, while emphasizing that vaccines remain a crucial key to significantly reducing these risks. The study published in the journal Nature Genetics has clarified why some communities in the UK and South Asia have a higher risk of contracting Covid-19. Based on previous research on genes, the researchers utilized artificial intelligence combined with new molecular technology to accurately identify the gene known as LZTF1 – which is believed to increase the risk of infection and death from Covid-19.
Explaining this, the lead researcher, Professor James Davies, stated that when lung cells encounter the virus causing the Covid-19 pandemic, one of their defense strategies is to undergo self-modification to prevent the virus from entering. This process reduces ACE-2 – an important protein on the cell surface – which is considered key for the virus to bind to the cells. However, for individuals carrying the LZTF1 gene, this process does not function effectively, making lung cells more susceptible to viral invasion.
Professor James Davies further noted that in addition to carrying the LZTF1 gene, other factors such as age also increase risk levels.
According to the scientists, it is important to note that the LZTF1 gene primarily affects the lungs but does not impact the immune system. This means that individuals at high risk can still be protected through vaccination against Covid-19.
