By inhibiting the development of a specific gene, researchers have created a breed of mice that is braver and bolder than other mouse species.
Gleb Shumyatsky and several other researchers were awarded the Nobel Prize alongside Eric Kandel for their study on the behavior of mice that had the stathmin gene knocked out. These mice dare to explore risky areas, even though their survival instincts typically lead them to avoid such places. Furthermore, they display significantly less fear compared to other mice.
The stathmin gene plays a crucial role in expressing innate fears as well as other fears encountered by mice throughout their lives. When exposed to dangerous environments and subjected to a loud noise caused by an electrical short, these genetically modified mice remain unfazed. This indicates a change in their perception of fear. However, their ability to navigate complex pathways remains comparable to that of normal mice.
The stathmin gene is essential for the formation of microtubules, which are structures within neurons that are vital for communication between these cells. When this gene is absent, the number of microtubules increases, leading to a loss of reflex capabilities in the cells. This reflex ability is crucial for processing emotional memories.
