Scientists at the Weizmann Institute of Science in Israel have discovered that stem cells from mice can self-assemble into embryonic structures that include intestines, brain cells, and heart tissue.
The structures created by the Weizmann Institute of Science are referred to as “synthetic embryos” because they form without undergoing the fertilization process between eggs and sperm, according to a report by the Guardian on August 3rd.
Comparison between natural and synthetic mouse embryos. (Image: Weizmann Institute of Science).
Researchers noted that the synthetic mouse embryos are 95% similar to natural embryos in terms of internal structure and genetic makeup of the cells. The components formed from the embryos have functional capabilities.
However, the scientists stated that the synthetic embryos do not have the ability to develop into living animals unless implanted into the uterus of a female mouse.
The study of synthetic embryos provides deeper insights into how tissues and organs form during the natural development of embryos.
Additionally, researchers believe that this study could reduce the number of animal experiments, paving the way for the creation of new sources of cells and tissues for human transplants.
For instance, skin cells from a leukemia patient could be transformed into bone marrow stem cells to treat their own cancer.
“The embryonic stem cells generate the entire synthetic embryo, including the placenta and yolk sac surrounding the embryo. This research and its applications excite us immensely,” said Professor Jacob Hanna, who leads the study.
