Scientists Successfully Transplant Human Chromosome into Mice, Paving New Path for Down Syndrome Treatments
Researchers have successfully transplanted a human chromosome into mice for the first time, marking a breakthrough that could lead to new treatments for Down syndrome and other disorders.
The genetically modified mice carry a copy of human chromosome 21, which is the smallest pair among the 23 pairs of human chromosomes and comprises approximately 225 genes.
This achievement represents 13 years of research by scientists at the National Health Institute in London and the Institute of Neurology. “We are optimistic that the successful grafting will allow us to delve deeper into the issues faced by Down syndrome patients,” said Victor Tybulewicz, the lead researcher.
Down syndrome affects 1 in 800 live births, resulting in delays in physical and neurological development. Individuals with this condition also face heart issues, hearing difficulties, and a higher risk of leukemia and Alzheimer’s disease.
Dr. Elizabeth Fisher from the Institute of Neurology believes that this new technology will help scientists identify the genes responsible for the symptoms of Down syndrome and the likelihood of developing other diseases.
The human chromosome was mixed with newly developed stem cells from mice, using a chemical that facilitates their compatibility. The stem cells carrying chromosome 21 were then injected into mouse embryos and implanted into a mother mouse. The result was a mouse with human chromosomes. Although the mouse appears normal, it exhibits various traits associated with Down syndrome.
The Down Syndrome Association in the UK welcomed this research, stating that it could positively impact the lives of those affected. “Any research that helps us understand why individuals with Down syndrome are more susceptible to other diseases is incredibly important, even though it must be acknowledged that it has not yet provided a specific treatment method for Down syndrome.”
M.T. (according to Reuters)
