In individuals suffering from chronic fatigue, certain parts of the brain shrink. This prolonged fatigue is a manifestation of changes in the immune system and abnormal developments in the brain. This is a warning signal.
Many people feel fatigued due to excessive busyness, leading to decreased work performance and increased errors, which can be quite distressing. The number of individuals experiencing chronic fatigue is on the rise, affecting not only adults but also adolescents and children. In daily life, when one feels tired but cannot rest, it becomes very challenging to eliminate fatigue.
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(Image: SK & DS) |
There are types of fatigue that can be treated with rest (healthy fatigue) and types that cannot be alleviated even with rest (unhealthy fatigue).
Research indicates that the primary substance responsible for fatigue is a immune-supporting factor known as TGF-b (Transforming Growth Factor beta). In healthy individuals, TGF-b levels increase during activity and decrease when resting, allowing fatigue to dissipate. However, in those with chronic fatigue, TGF-b levels do not decrease even when at rest.
TGF-b acts as a signaling molecule for immune cells in response to “foreign invaders.” When we experience psychological stress or catch a cold virus, the effectiveness of immune cells diminishes. Consequently, TGF-b continues to be released excessively, making the synthesis of GABA—a neurotransmitter that facilitates communication between nerve cells—difficult. This hampers the brain’s ability to communicate effectively, leading to reduced attention and increased fatigue. In individuals suffering from chronic fatigue, certain parts of the brain shrink. In summary, chronic fatigue involves changes in the immune system and abnormal developments in the brain, signaling a state of danger.
Recently, to treat chronic fatigue syndrome, doctors have been using SSRIs (Selective Serotonin Reuptake Inhibitors) which are effective in increasing serotonin levels. SSRIs have shown positive results in 40% of patients with chronic fatigue syndrome. Another approach is the use of traditional Chinese medicine to enhance immune function.
Efforts to eliminate fatigue are still under investigation. Many “nutritional drinks” advertised as cures for fatigue on the market are not credible, as the mechanisms behind fatigue are still being explored. However, studies in Japan suggest that antioxidants such as vitamin C or citric acid, along with certain amino acids, may help alleviate fatigue. Additionally, taking leisurely walks to enjoy beautiful scenery is a simple yet effective way to combat fatigue.
